Clinical Studies with the use of CBD

below you will find topics of CBD testing in the fields of Mental Health, Physical Health Neurological Disorders and Skin Conditions.  Located with in each segment are links to testing information that are documented and listed in the pubmed.gov for education and reading so you will better understand the benefits of using CBD.

Mental Health Studies & CBD

PMID: 28061971 The Endocannabinoid System and Anxiety.

PMID: 23653088 Plant-based medicines for anxiety disorders, part 2.

PMID: 20829306 Neural basis of anxiolytic effects of cannabidiol (CBD) in generalized social anxiety disorder.

PMID: 24923339  Antidepressant-like and anxiolytic-like effects of cannabidiol: a chemical compound of Cannabis sativa.

PMID: 21307846 Cannabidiol reduces the anxiety induced by simulated public speaking in treatment-naïve social phobia patients.

PMID: 25004388 Central anandamide deficiency predicts stress-induced anxiety: behavioral reversal through endocannabinoid augmentation.

PMID: 20945065  The anxiolytic-like effects of cannabidiol injected into the bed nucleus of the stria terminalis are mediated by 5-HT1A receptors.

PMID: 23298518 The anxiolytic effect of cannabidiol on chronically stressed mice depends on hippocampal neurogenesis: involvement of the endocannabinoid system.

PMID: 28424834 Effect of prior foot shock stress and Δ9-tetrahydrocannabinol, cannabidiolic acid, and cannabidiol on anxiety-like responding in the light-dark emergence test in rats.

PMID: 28268256 Cannabidiol regulation of emotion and emotional memory processing: relevance for treating anxiety-related and substance abuse disorders.

PMID: 27768570 Effectiveness of Cannabidiol Oil for Pediatric Anxiety and Insomnia as Part of Posttraumatic Stress Disorder: A Case Report.

PMID: 26845556 A Systematic Review of Plant-Derived Natural Compounds for Anxiety Disorders.

PMID: 28861510 Cannabidiol Does Not Dampen Responses to Emotional Stimuli in Healthy Adults.

PMID: 14583744 Effects of cannabidiol (CBD) on regional cerebral blood flow.

PMID: 22729452 CBD as an anxiolytic drug.

Physical Health Studies & CBD

PMID: 22850623 Anti-inflammatory role of cannabidiol.

PMID: 27435265 Cannabinoids, inflammation, and fibrosis.

PMID: 24419242 The endocannabinoid system: an emerging key player in inflammation.

PMID: 19199042 Cannabinoids, endocannabinoids, and related analogs in inflammation.

PMID: 22163000 Cannabidiol reduces intestinal inflammation through the control of neuroimmune axis.

PMID: 22585736 Cannabinoids suppress inflammatory and neuropathic pain by targeting α3 glycine receptors.

PMID: 17384130 Cannabidiol attenuates high glucose-induced endothelial cell inflammatory response and barrier disruption.

PMID: 21238581 Cannabidiol as an emergent therapeutic strategy for lessening the impact of inflammation on oxidative stress.

PMID: 28867485 Mechanisms of action of cannabidiol in adoptively transferred experimental autoimmune encephalomyelitis.

PMID: 22265864 Cannabidiol, a non-psychotropic plant-derived cannabinoid, decreases inflammation in a murine model of acute lung injury.

PMID: 22163051 Cannabidiol reduces Aβ-induced neuroinflammation and promotes hippocampal neurogenesis through PPARγ involvement.

PMID: 28115138 Endocannabinoid 2-arachidonoylglycerol protects inflammatory insults from sulfur dioxide inhalation via cannabinoid receptors in the brain.

PMID: 27430346 Protective effect of cannabidiol on hydrogen peroxide‑induced apoptosis, inflammation and oxidative stress in nucleus pulposus cells.

Neurological Disorders Studies & CBD

PMID: 27428009 Cannabinoids for fibromyalgia.

PMID: 22696383 Cannabinoids for epilepsy.

PMID: 25346637 Seizing an opportunity for the endocannabinoid system.

PMID: 26142529 The safety and efficacy of 3% Cannabis seeds extract cream for reduction of human cheek skin sebum and erythema content.

PMID: 25061872 Cannabidiol exerts sebostatic and anti-inflammatory effects on human sebocytes.

PMID: 19608284 The endocannabinoid system of the skin in health and disease.

PMID: 18596221 Endocannabinoids enhance lipid synthesis and apoptosis of human sebocytes via cannabinoid receptor-2-mediated signaling.

PMID: 21628127 Endocannabinoid signaling and epidermal differentiation.

PMID: 27094344 Differential effectiveness of selected non-psychotropic phytocannabinoids on human sebocyte functions.

PMID: 24237632 Report of a parent survey of cannabidiol-enriched cannabis use in pediatric treatment-resistant epilepsy.

PMID: 25282526 Cannabis, cannabidiol, and epilepsy–from receptors to clinical response.

PMID: 7413719 Chronic administration of cannabidiol to healthy volunteers and epileptic patients.

PMID: 21441624  Endocannabinoid system protects against cryptogenic seizures.

PMID: 24854329 Cannabidiol: pharmacology and potential therapeutic role in epilepsy and other neuropsychiatric disorders.

PMID: 850145 Cannabidiol–antiepileptic drug comparisons and interactions in experimentally induced seizures in rats.

PMID: 28087250 Pharmacology of cannabinoids in the treatment of epilepsy.

PMID: 28190698 Therapeutic effects of cannabinoids in animal models of seizures, epilepsy, epileptogenesis, and epilepsy-related neuroprotection.

PMID: 28367124 Protective Effects of Cannabidiol against Seizures and Neuronal Death in a Rat Model of Mesial Temporal Lobe Epilepsy.

Skin Conditions Studies & CBD

PMID: 19608284 The endocannabinoid system of the skin in health and disease.

PMID: 26142529 The safety and efficacy of 3% Cannabis seeds extract cream for reduction of human cheek skin sebum and erythema content.

PMID: 25061872  Cannabidiol exerts sebostatic and antiinflammatory effects on human sebocytes.

PMID: 18596221 Endocannabinoids enhance lipid synthesis and apoptosis of human sebocytes via cannabinoid receptor-2-mediated signaling.

PMID: 21628127 Endocannabinoid signaling and epidermal differentiation.

PMID: 27094344 Differential effectiveness of selected non-psychotropic phytocannabinoids on human sebocyte functions implicates their introduction in dry/seborrhoeic skin and acne treatment.

These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure or prevent any disease.